mouse CETN2 Adenovirus
This is an Adenovirus expressing Mouse Cetn2.
ADV-255320
Ad-m-CETN2
Ready-to-use Adenovirus expressing Mouse Cetn2 (centrin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110034A02Rik; AI326150; Calt; caltractin
Description (Vector)
Plays a fundamental role in microtubule-organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CEP110|Function: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer|Function: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
Gene ID
26370
Gene Name (Vector)
centrin 2
Gene Symbol
Cetn2
ORF Size (aa)
519
RefSeq ID
NM_019405
RefSeq Synonyms
NM_019405, BC013545,
Species
mouse
UniGene ID
Mm.24643
Recently Viewed Products
AAV-m-PHC3
Cat No: AAV-268518
AAV-m-CITED4
Cat No: AAV-255524
Ad-m-BCKDHA
Cat No: ADV-253870
AAV-GFAP(2.2)-roGFP1
Cat No: VB1178
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.