mouse CAMK4 Adenovirus
This is an Adenovirus expressing Human PI16.
ADV-254449
Ad-m-CAMK4
Ready-to-use Adenovirus expressing Mouse Camk4 (calcium/calmodulin-dependent protein kinase IV). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A430110E23Rik; AI666733; CaMKIV; CaMKIV/Gr; D18Bwg0362e
Description (Vector)
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consodilation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteolclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphrylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Gene ID
12326
Gene Name (Vector)
calcium/calmodulin-dependent protein kinase IV
Gene Symbol
Camk4
ORF Size (aa)
1410
ORF Size (bp)
1410 bp
RefSeq ID
NM_009793
RefSeq Synonyms
NM_009793, BC070420,
Species
mouse
UniGene ID
Mm.222329
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.