mouse C80913 Adenovirus
This is an Adenovirus expressing Mouse C80913.
ADV-254320
Ad-m-C80913
Ready-to-use Adenovirus expressing Mouse Uri1 (URI1, prefoldin-like chaperone). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C80913; NNX3; Rmp
Description (Vector)
Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein|Function: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival sigaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity at mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.
Gene ID
19777
Gene Name (Vector)
URI1, prefoldin-like chaperone
Gene Symbol
Uri1
ORF Size (aa)
1374
ORF Size (bp)
1374 bp
RefSeq ID
NM_011274
RefSeq Synonyms
NM_011274, BC023029,
Species
mouse
UniGene ID
Mm.387220
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.