mouse BAZ1B Adenovirus
This is an Adenovirus expressing Mouse Baz1b.
ADV-253638
Ad-m-BAZ1B
Ready-to-use Adenovirus expressing Mouse Baz1b (bromodomain adjacent to zinc finger domain, 1B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C87820; Wbscr9; WSTF
Description (Vector)
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. In the WINAC complex, plays an essential role by targeting the complex to acetylated histones, an essential step for VDR-promoter association.
Gene ID
22385
Gene Name (Vector)
bromodomain adjacent to zinc finger domain, 1B
Gene Symbol
Baz1b
ORF Size (aa)
4440
ORF Size (bp)
4440 bp
RefSeq ID
NM_011714
RefSeq Synonyms
NM_011714, BC141399,
Species
mouse
UniGene ID
Mm.40331
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.