mouse ARID5B Adenovirus

Name 
Ad-m-ARID5B
Cat No 
ADV-252993
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Mouse Arid5b.

ADV-252993
Ad-m-ARID5B

Ready-to-use Adenovirus expressing Mouse Arid5b (AT rich interactive domain 5B (MRF1-like)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
4930580B11; 5430435G07Rik; AI467247; Desrt; Mrf2; Mrf2alpha; Mrf2beta
Description (Vector)
Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.
Gene ID
71371
Gene Name (Vector)
AT rich interactive domain 5B (MRF1-like)
Gene Symbol
Arid5b
ORF Size (aa)
3567
ORF Size (bp)
3567 bp
RefSeq ID
NM_023598
RefSeq Synonyms
NM_023598, BC165988,
Species
mouse
UniGene ID
Mm.440357

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.