mouse 1500003O03RIK Adenovirus
This is an Adenovirus expressing Mouse Chp1.
ADV-250203
Ad-m-1500003O03RIK
Ready-to-use Adenovirus expressing Mouse Chp1 (calcineurin-like EF hand protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1500003O03Rik; AA960066; AI046351; Cahp; Chp; p24; Sid470p; vac
Description (Vector)
Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.
Gene ID
56398
Gene Name (Vector)
calcineurin-like EF hand protein 1
Gene Symbol
Chp1
ORF Size (aa)
588
ORF Size (bp)
588 bp
RefSeq ID
NM_019769
RefSeq Synonyms
NM_019769, BC064784, BC054733,
Species
mouse
UniGene ID
Mm.214765
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.