mouse DDX39B Adenovirus
This is an Adenovirus expressing Mouse Ddx39b.
ADV-250029
Ad-m-DDX39B
Ready-to-use Adenovirus expressing Mouse Ddx39b (DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
0610030D10Rik; AI428441; Bat-1; Bat1; Bat1a; D17H6S81E; D17H6S81E-1; D6S81Eh
Description (Vector)
Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4|Function: Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2 and ALYREF/THOC4.
Gene ID
53817
Gene Name (Vector)
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
Gene Symbol
Ddx39b
ORF Size (aa)
1287
ORF Size (bp)
1287 bp
RefSeq ID
NM_019693
RefSeq Synonyms
NM_019693, NM_001252457, BC024859, BC011067,
Species
mouse
UniGene ID
Mm.439827
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.