human EGLN1 Adenovirus
This is an Adenovirus expressing Human EGLN1.
ADV-233019
Ad-h-EGLN1
Ready-to-use Adenovirus expressing Human EGLN1 (egl-9 family hypoxia inducible factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C1orf12; ECYT3; egl nine homolog 1; egl nine-like protein 1; HALAH; HIFPH2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH2; HPH-2; hypoxia-inducible factor prolyl hydroxylase 2; PHD2; prolyl hydroxylase domain-containing protein 2; SM20; SM-20; zinc finger MYND domain-containing protein 6; ZMYND6
Description (eCommerce)
PHD2 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
Description (Vector)
EGLN1 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
Gene ID
54583
Gene Name (eCommerce)
egl-9 family hypoxia inducible factor 1
Gene Name (Vector)
egl-9 family hypoxia inducible factor 1
Gene Symbol
EGLN1
HGNC ID
HGNC:1232
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
387
Protein Name (eCommerce)
Egl nine homolog 1
RefSeq ID
NM_022051
RefSeq Synonyms
NM_022051, BC005369,
Research Areas
Angiogenesis,Cancer,Cardiac Development,Cardiology,Cardiovascular,HIF-1 Signaling,Hypoxia,Kidney Cancer,Signal Transduction,Transcription Factor/Regulator,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
PHD2 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
UniProt ID (eCommerce)
Q9GZT9
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.