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human ASPM Adenovirus

Name 
Ad-h-ASPM
Cat No 
ADV-233018
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ASPM.

ADV-233018
Ad-h-ASPM

Ready-to-use Adenovirus expressing Human ASPM (abnormal spindle microtubule assembly). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Abnormal spindle protein homolog; abnormal spindle-like microcephaly-associated protein; ASP; asp (abnormal spindle) homolog, microcephaly associated; Asp homolog; Calmbp1; MCPH5
Description (eCommerce)
ASPM (abnormal spindle-like microcephaly associated) is also known as MCPH5 (autosomal recessive primary microcephaly 5). Defects in ASPM are the cause of microcephaly primary type 5 or microcephaly vera, an autosomal recessive disease characterized by reduced head circumference, small cerebral cortex, and reduced brain weight. At the cellular level, MCPH5 is important to mitotic spindle function and may play a preferential role in prenatal neurogenesis.
Description (Vector)
ASPM is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
259266
Gene Name (eCommerce)
abnormal spindle microtubule assembly
Gene Name (Vector)
abnormal spindle microtubule assembly
Gene Symbol
ASPM
HGNC ID
HGNC:19048
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3429
ORF Size (bp)
3429 bp
Protein Name (eCommerce)
Abnormal spindle-like microcephaly-associated protein
RefSeq ID
NM_018136
RefSeq Synonyms
NM_018136, NM_001206846, BC034607,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Neurodevelopment,Signal Transduction,Spermatogenesis,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
ASPM (abnormal spindle-like microcephaly associated) is also known as MCPH5 (autosomal recessive primary microcephaly 5). Defects in ASPM are the cause of microcephaly primary type 5 or microcephaly vera, an autosomal recessive disease characterized by reduced head circumference, small cerebral cortex, and reduced brain weight. At the cellular level, MCPH5 is important to mitotic spindle function and may play a preferential role in prenatal neurogenesis.
UniProt ID (eCommerce)
Q8IZT6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.