human IRS1 Adenovirus
This is an Adenovirus expressing Human IRS1.
ADV-232624
Ad-h-IRS1
Ready-to-use Adenovirus expressing Human IRS1 (insulin receptor substrate 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HIRS-1; insulin receptor substrate 1; IRS-1
Description (eCommerce)
The insulin receptor substrate 1 (IRS1) is one of four members of the IRS family (IRS1-4) that mediates intracellular signaling downstream of the IGF1 and insulin receptors. Phosphorylation of IRS1 by activated receptors leads to binding of IRS to the SH2 domains of effector proteins such as PI3K, Grb2, nck, and SHP2. The downstream effects of insulin and IGF1 signaling via IRSs on the cell are pleiotropic and include various responses such as glucose transport, glycogen synthesis, protein synthesis, antilipolysis, and gluconeogenesis. Polymorphisms in IRS1 may contribute to the etiology of non-insulin-dependent diabetes mellitus (NIDDM).
Description (Vector)
IRS1 encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
Gene ID
3667
Gene Name (eCommerce)
insulin receptor substrate 1
Gene Name (Vector)
insulin receptor substrate 1
Gene Symbol
IRS1
HGNC ID
HGNC:6125
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3729
ORF Size (bp)
3729 bp
Protein Name (eCommerce)
Insulin receptor substrate 1
RefSeq ID
NM_005544
RefSeq Synonyms
NM_005544, BC053895,
Research Areas
Aging,Angiogenesis,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cytokine Signaling,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,Glioma,IFN Signaling,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Leptin Signaling,Lung Cancer,Metabolism/Metabolic Process,MicroRNAs in Cancer,mTOR Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prolactin Signaling,SCF-KIT Signaling,Signal Transduction,TNF Signaling
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,transcription_translation,immunology,metabolism,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
The insulin receptor substrate 1 (IRS1) is one of four members of the IRS family (IRS1-4) that mediates intracellular signaling downstream of the IGF1 and insulin receptors. Phosphorylation of IRS1 by activated receptors leads to binding of IRS to the SH2 domains of effector proteins such as PI3K, Grb2, nck, and SHP2. The downstream effects of insulin and IGF1 signaling via IRSs on the cell are pleiotropic and include various responses such as glucose transport, glycogen synthesis, protein synthesis, antilipolysis, and gluconeogenesis. Polymorphisms in IRS1 may contribute to the etiology of non-insulin-dependent diabetes mellitus (NIDDM).
UniGene ID
Hs.471508
UniProt ID (eCommerce)
P35568
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.