human EYA4 Adenovirus

Name 
Ad-h-EYA4
Cat No 
ADV-231559
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human EYA4.

ADV-231559
Ad-h-EYA4

Ready-to-use Adenovirus expressing Human EYA4 (EYA transcriptional coactivator and phosphatase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CMD1J; DFNA10; dJ78N10.1 (eyes absent); eyes absent homolog 4; eyes absent-like protein 4
Description (eCommerce)
EYA4 (eyes absent homolog 4) is a member of the eyes absent (EYA) family of proteins. EYA4 may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in the EYA4 gene are the cause of deafness utosomal dominant type 10 (DFNA10) and dilated cardiomyopathy 1J (CMD1J).
Description (Vector)
EYA4 encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant nonsyndromic sensorineural 10 locus. Defects in this gene are also associated with dilated cardiomyopathy 1J. Three transcript variants encoding distinct isoforms have been identified for this gene.
Gene ID
2070
Gene Name (eCommerce)
EYA transcriptional coactivator and phosphatase 4
Gene Name (Vector)
EYA transcriptional coactivator and phosphatase 4
Gene Symbol
EYA4
HGNC ID
HGNC:3522
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1851
ORF Size (bp)
1851 bp
Protein Name (eCommerce)
Eyes absent homolog 4
RefSeq ID
NM_004100
RefSeq Synonyms
NM_172105, NM_172103, NM_004100, NM_001301013, NM_001301012, BC041063,
Research Areas
Cardiology,Cardiomyopathy,Cardiovascular,Chromatin Remodeling,DNA Damage/Repair,Kinase/Phosphatase,Neurobiology,Phosphatase,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
EYA4 (eyes absent homolog 4) is a member of the eyes absent (EYA) family of proteins. EYA4 may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in the EYA4 gene are the cause of deafness utosomal dominant type 10 (DFNA10) and dilated cardiomyopathy 1J (CMD1J).
UniGene ID
Hs.596680
UniProt ID (eCommerce)
O95677

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.