human HIF1A Adenovirus

Name 
Ad-h-HIF1A
Cat No 
ADV-230457
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human HIF1A.

ADV-230457
Ad-h-HIF1A

Ready-to-use Adenovirus expressing Human HIF1A (hypoxia inducible factor 1 alpha subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARNT-interacting protein; basic-helix-loop-helix-PAS protein MOP1; bHLHe78; class E basic helix-loop-helix protein 78; HIF1; HIF-1A; HIF-1alpha; HIF-1-alpha; HIF1-ALPHA; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1-alpha; hypoxia-inducible factor1alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8
Description (eCommerce)
Hypoxia-inducible factor-1 (HIF1) is a basic helix-loop-helix (bHLH)-PER-ARNT-sim (PAS) transcription factor that plays a role in the cellular response to hypoxia. HIF1 is a heterodimer of an HIF1-alpha and HIF1-beta subunit. During normoxia, HIF-1alpha is regulated by ubiquitination and interaction with the von-Hippel-Lindau tumor suppressor protein (pVHL).
Description (Vector)
HIF1A encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Gene ID
3091
Gene Name (eCommerce)
hypoxia inducible factor 1 subunit alpha
Gene Name (Vector)
hypoxia inducible factor 1 alpha subunit
Gene Symbol
HIF1A
HGNC ID
HGNC:4910
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2481
ORF Size (bp)
2481 bp
Protein Name (eCommerce)
Hypoxia-inducible factor 1-alpha
RefSeq ID
NM_001530
RefSeq Synonyms
NM_181054, NM_001530, NM_001243084, BC012527,
Research Areas
Angiogenesis,Apoptosis,Cancer,Cardiac Development,Cardiology,Cardiovascular,Gene Expression,HIF-1 Signaling,Histone Modification,Hypoxia,Immunology,Interleukin Signaling,Kidney Cancer,mTOR Signaling,Neurobiology,Neurodevelopment,Notch Signaling,Signal Transduction,Transcription Factor/Regulator,Ubiquitination,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Hypoxia-inducible factor-1 (HIF1) is a basic helix-loop-helix (bHLH)-PER-ARNT-sim (PAS) transcription factor that plays a role in the cellular response to hypoxia. HIF1 is a heterodimer of an HIF1-alpha and HIF1-beta subunit. During normoxia, HIF-1alpha is regulated by ubiquitination and interaction with the von-Hippel-Lindau tumor suppressor protein (pVHL).
UniGene ID
Hs.597216
UniProt ID (eCommerce)
Q16665

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.