human XPO7 Adenovirus
This is an Adenovirus expressing Human XPO7.
ADV-227920
Ad-h-XPO7
Ready-to-use Adenovirus expressing Human XPO7 (exportin 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EXP7; exportin-7; RAN binding protein 16; Ran-binding protein 16; RANBP16
Description (eCommerce)
RanBP16 mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. RanBP16 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UIA9].
Description (Vector)
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.(supplied by OMIM, Jul 2002)
Gene ID
23039
Gene Name (eCommerce)
exportin 7
Gene Name (Vector)
exportin 7
Gene Symbol
XPO7
HGNC ID
HGNC:14108
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3264
ORF Size (bp)
3264 bp
Protein Name (eCommerce)
Exportin-7
RefSeq ID
NM_015024
RefSeq Synonyms
NM_015024, BC030785,
Research Areas
mRNA transport,RNA Transport
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
RanBP16 mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. RanBP16 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UIA9].
UniGene ID
Hs.172685
UniProt ID (eCommerce)
Q9UIA9
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.