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human VKORC1 Adenovirus

Name 
Ad-h-VKORC1
Cat No 
ADV-227487
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human VKORC1.

ADV-227487
Ad-h-VKORC1

Ready-to-use Adenovirus expressing Human VKORC1 (vitamin K epoxide reductase complex subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
EDTP308; MST134; MST576; VKCFD2; VKOR
Description (Vector)
Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.
Gene ID
79001
Gene Name (Vector)
vitamin K epoxide reductase complex subunit 1
Gene Symbol
VKORC1
HGNC ID
HGNC:23663
ORF Size (aa)
492
RefSeq ID
NM_206824
RefSeq Synonyms
NM_206824, NM_024006, NM_001311311, BC002911,
Species
human
UniGene ID
Hs.324844

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.