human VHLL Adenovirus
This is an Adenovirus expressing Human VHLL.
ADV-227475
Ad-h-VHLL
Ready-to-use Adenovirus expressing Human VHLL (von Hippel-Lindau tumor suppressor like). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
VHLP; VLP
Description (Vector)
Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.
Gene ID
391104
Gene Name (Vector)
von Hippel-Lindau tumor suppressor like
Gene Symbol
VHLL
HGNC ID
HGNC:30666
ORF Size (aa)
420
RefSeq ID
NM_001004319
RefSeq Synonyms
NM_001004319, BC130598, BC130596,
Species
human
UniGene ID
Hs.532378
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.