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human UVRAG Adenovirus

Name 
Ad-h-UVRAG
Cat No 
ADV-227372
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human UVRAG.

ADV-227372
Ad-h-UVRAG

Ready-to-use Adenovirus expressing Human UVRAG (UV radiation resistance associated). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
beclin 1 binding protein; DHTX; disrupted in heterotaxy; p63; UV radiation resistance-associated gene protein; VPS38
Description (eCommerce)
UV radiation resistance associated gene (UVRAG) was first identified as a gene that could complement UV sensitivity in xeroderma pigmentosum cells. UVRAG may have tumor suppressor activity as mutations in the UVRAG gene have been associated with various human colon cancer cells and tissues. UVRAG has been shown to interact with Beclin 1 (Bcl-2-interacting protein), a protein that forms a complex with class III PI-3-kinase (PI3KC3) and is involved in autophagy. In this complex, UVRAG is proposed to function as a positive regulator of autophagy and a negative regulator of the growth of tumor cells.
Description (Vector)
UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Gene ID
7405
Gene Name (eCommerce)
UV radiation resistance associated
Gene Name (Vector)
UV radiation resistance associated
Gene Symbol
UVRAG
HGNC ID
HGNC:12640
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2100
ORF Size (bp)
2100 bp
Protein Name (eCommerce)
UV radiation resistance-associated gene protein
RefSeq ID
NM_003369
RefSeq Synonyms
NM_003369, BC064837,
Research Areas
Autophagy,DNA Damage/Repair,Lysosome
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
UV radiation resistance associated gene (UVRAG) was first identified as a gene that could complement UV sensitivity in xeroderma pigmentosum cells. UVRAG may have tumor suppressor activity as mutations in the UVRAG gene have been associated with various human colon cancer cells and tissues. UVRAG has been shown to interact with Beclin 1 (Bcl-2-interacting protein), a protein that forms a complex with class III PI-3-kinase (PI3KC3) and is involved in autophagy. In this complex, UVRAG is proposed to function as a positive regulator of autophagy and a negative regulator of the growth of tumor cells.
UniGene ID
Hs.202470
UniProt ID (eCommerce)
Q9P2Y5

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.