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human UFD1L Adenovirus

Name 
Ad-h-UFD1L
Cat No 
ADV-227129
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human UFD1L.

ADV-227129
Ad-h-UFD1L

Ready-to-use Adenovirus expressing Human UFD1L (ubiquitin fusion degradation 1 like (yeast)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
UB fusion protein 1; ubiquitin fusion degradation 1 like; Ubiquitin fusion degradation protein 1; ubiquitin fusion degradation protein 1 homolog; ubiquitin recognition factor in ER-associated degradation protein 1; UFD1L
Description (eCommerce)
Ubiquitin fusion degradation protein 1 homolog (UFD1) forms a dimer with Npl4 (nuclear protein localization 4) and can associate with the ATPase, p97/VCP, to form a ternary complex involved in the ubiquitin-proteasome pathway. The UFD1-p97-Npl4 complex functions to recognize ubiquitin-tagged proteins and facilitate their presentation to the 26S proteasome for degradation. This ternary complex has also been shown to play an important role in mitotic spindle disassembly. Hemizygosity in the gene which encodes UFD1 (UFD1L) is the cause of some catch 22-associated developmental defects. Additionally, the UFD1L gene has also been implicated in the neurodevelopment al origin of schizophrenia.
Description (Vector)
UFD1L forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18.
Gene ID
7353
Gene Name (eCommerce)
ubiquitin recognition factor in ER associated degradation 1
Gene Name (Vector)
ubiquitin fusion degradation 1 like (yeast)
Gene Symbol
UFD1L
HGNC ID
HGNC:12520
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
924
Protein Name (eCommerce)
Ubiquitin fusion degradation protein 1 homolog
RefSeq ID
NM_005659
RefSeq Synonyms
NM_005659, NM_001035247, BC005087, BC001049,
Research Areas
Cell Biology,Cell Cycle,Cell Division,Neurobiology,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,neurobiology,genetics
Species
human
Target Sentence
Ubiquitin fusion degradation protein 1 homolog (UFD1) forms a dimer with Npl4 (nuclear protein localization 4) and can associate with the ATPase, p97/VCP, to form a ternary complex involved in the ubiquitin-proteasome pathway. The UFD1-p97-Npl4 complex functions to recognize ubiquitin-tagged proteins and facilitate their presentation to the 26S proteasome for degradation. This ternary complex has also been shown to play an important role in mitotic spindle disassembly. Hemizygosity in the gene which encodes UFD1 (UFD1L) is the cause of some catch 22-associated developmental defects. Additionally, the UFD1L gene has also been implicated in the neurodevelopment al origin of schizophrenia.
UniGene ID
Hs.474213
UniProt ID (eCommerce)
Q92890

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.