human TRIM25 Adenovirus
This is an Adenovirus expressing Human TRIM25.
ADV-226415
Ad-h-TRIM25
Ready-to-use Adenovirus expressing Human TRIM25 (tripartite motif containing 25). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E3 ubiquitin/ISG15 ligase TRIM25; EFP; estrogen-responsive finger protein; RING finger protein 147; RING-type E3 ubiquitin transferase; RING-type E3 ubiquitin transferase TRIM25; RNF147; tripartite motif protein TRIM25; tripartite motif-containing protein 25; ubiquitin/ISG15-conjugating enzyme TRIM25; Z147; Zinc finger protein 147; zinc finger protein 147 (estrogen-responsive finger protein); zinc finger protein-147; ZNF147
Description (eCommerce)
TRIM (tripartite motif) proteins, also known as RBCC (RING, B-box, coiled-coil) proteins, are defined by the presence of a tripartite structural motif composed of a RING domain, one or two B-box motifs, and a coiled-coil region. TRIM proteins have been found to be involved in a variety of cellular processes such as apoptosis, proliferation, differentiation, and innate immunity. Of these processes, the most intriguing is their involvement in the innate immune response. TRIM25 has been demonstrated to mediate ubiquitination of the cytosolic receptor retinoic acid-inducible gene-I (RIG-I) in response to viral infection.
Description (Vector)
TRIM25 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.
Gene ID
7706
Gene Name (eCommerce)
tripartite motif containing 25
Gene Name (Vector)
tripartite motif containing 25
Gene Symbol
TRIM25
HGNC ID
HGNC:12932
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1893
ORF Size (bp)
1893 bp
Protein Name (eCommerce)
E3 ubiquitin/ISG15 ligase TRIM25
RefSeq ID
NM_005082
RefSeq Synonyms
NM_005082, BC042541, BC016924,
Research Areas
Breast Cancer,Cancer,Cell Cycle,Cytokine Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,NF-kB Signaling,Response to Virus,Signal Transduction,T-cell Receptor Signaling,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,cell_cycle,immunology,infectious_disease,immunology,signal_transduction,infectious_disease,signal_transduction,immunology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
TRIM (tripartite motif) proteins, also known as RBCC (RING, B-box, coiled-coil) proteins, are defined by the presence of a tripartite structural motif composed of a RING domain, one or two B-box motifs, and a coiled-coil region. TRIM proteins have been found to be involved in a variety of cellular processes such as apoptosis, proliferation, differentiation, and innate immunity. Of these processes, the most intriguing is their involvement in the innate immune response. TRIM25 has been demonstrated to mediate ubiquitination of the cytosolic receptor retinoic acid-inducible gene-I (RIG-I) in response to viral infection.
UniGene ID
Hs.528952
UniProt ID (eCommerce)
Q14258
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.