human TP53BP2 Adenovirus

Name 
Ad-h-TP53BP2
Cat No 
ADV-226231
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human TP53BP2.

ADV-226231
Ad-h-TP53BP2

Ready-to-use Adenovirus expressing Human TP53BP2 (tumor protein p53 binding protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
53BP2; apoptosis-stimulating of p53 protein 2; apoptosis-stimulating protein of p53, 2; ASPP2; BBP; BCL2-binding protein; p53-binding protein 2; P53BP2; PPP1R13A; renal carcinoma antigen NY-REN-51; tumor suppressor p53-binding protein 2
Description (eCommerce)
The Apoptosis-Stimulating Protein of P53 (ASPP) family of proteins is comprised of ASPP1, ASPP2 and iASPP. ASPP1 and ASPP2 function to direct the cell away from cell cycle arrest and towards death by activating p53 family members, while iASPP functions to inhibit p53 mediated apoptosis. ASPP proteins have been shown to interact with p53, Bcl-2, and ReLA/p65.
Description (Vector)
TP53BP2 encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
7159
Gene Name (eCommerce)
tumor protein p53 binding protein 2
Gene Name (Vector)
tumor protein p53 binding protein 2
Gene Symbol
TP53BP2
HGNC ID
HGNC:12000
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3405
ORF Size (bp)
3405 bp
Protein Name (eCommerce)
Apoptosis-stimulating of p53 protein 2
RefSeq ID
NM_005426
RefSeq Synonyms
NM_005426, NM_001031685, BC058918, BC040247,
Research Areas
Apoptosis,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Hippo Signaling,Kinase/Phosphatase,Neurobiology,Neurodevelopment,Signal Transduction
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
The Apoptosis-Stimulating Protein of P53 (ASPP) family of proteins is comprised of ASPP1, ASPP2 and iASPP. ASPP1 and ASPP2 function to direct the cell away from cell cycle arrest and towards death by activating p53 family members, while iASPP functions to inhibit p53 mediated apoptosis. ASPP proteins have been shown to interact with p53, Bcl-2, and ReLA/p65.
UniGene ID
Hs.523968
UniProt ID (eCommerce)
Q13625

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.