human TNNT1 Adenovirus

Name 
Ad-h-TNNT1
Cat No 
ADV-226139
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human TNNT1.

ADV-226139
Ad-h-TNNT1

Ready-to-use Adenovirus expressing Human TNNT1 (troponin T1, slow skeletal type). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ANM; NEM5; STNT; TNT; TNTS
Description (Vector)
TNNT1 encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
7138
Gene Name (Vector)
troponin T1, slow skeletal type
Gene Symbol
TNNT1
HGNC ID
HGNC:11948
ORF Size (aa)
789
RefSeq ID
NM_003283
RefSeq Synonyms
NM_003283, NM_001291774, NM_001126133, NM_001126132, BC107798, BC034143, BC010963,
Species
human
UniGene ID
Hs.631558

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.