human TIMM8A Adenovirus
This is an Adenovirus expressing Human TIMM8A.
ADV-225522
Ad-h-TIMM8A
Ready-to-use Adenovirus expressing Human TIMM8A (translocase of inner mitochondrial membrane 8 homolog A (yeast)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DDP; DDP1; deafness dystonia protein 1; deafness/dystonia peptide; DFN1; mitochondrial import inner membrane translocase subunit Tim8 A; MTS; TIM8; translocase of inner mitochondrial membrane 8 homolog A; X-linked deafness dystonia protein
Description (eCommerce)
Translocase of inner mitochondrial membrane 8 homolog A (TIMM8A) is a translocase involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The TIMM8A gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS), and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in the TIMM8A gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. Along with TIMM13, TIMM8A forms a 70 kDa heterohexamer [taken from NCBI Entrez Gene (Gene ID: 1678)].
Description (Vector)
This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
1678
Gene Name (eCommerce)
translocase of inner mitochondrial membrane 8A
Gene Name (Vector)
translocase of inner mitochondrial membrane 8 homolog A (yeast)
Gene Symbol
TIMM8A
HGNC ID
HGNC:11817
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
294
Protein Name (eCommerce)
Mitochondrial import inner membrane translocase subunit Tim8 A
RefSeq ID
NM_004085
RefSeq Synonyms
NM_004085, NM_001145951, BC070284, BC015093, BC006994,
Research Areas
Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodevelopment,Transport
Research Areas (Faceted)
metabolism,cell_biology,neurobiology,developmental_biology
Species
human
Target Sentence
Translocase of inner mitochondrial membrane 8 homolog A (TIMM8A) is a translocase involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The TIMM8A gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS), and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in the TIMM8A gene also cause Jensen syndrome; an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. Along with TIMM13, TIMM8A forms a 70 kDa heterohexamer [taken from NCBI Entrez Gene (Gene ID: 1678)].
UniGene ID
Hs.447877
UniProt ID (eCommerce)
O60220
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.