human TIMELESS Adenovirus

Name
Ad-h-TIMELESS

Cat No
ADV-225506

Availability
4-5 weeks

This is an Adenovirus expressing Human TIMELESS.

ADV-225506

Ad-h-TIMELESS

Ready-to-use Adenovirus expressing Human TIMELESS (timeless circadian clock). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

hTIM; protein timeless homolog; TIM; TIM1; timeless circadian clock 1; timeless homolog; Tof1 homolog

Description (eCommerce)

Timeless was first identified in Drosophila as a transcriptional regulator involved in the fly circadian rhythm. In mice, humans and yeast, the homologs of drosophila timeless have been observed to play a role in the DNA damage checkpoint response. Human timeless has been shown to interact with the circadian clock protein cryptochrome 2 as well as the DNA checkpoint proteins Chk1 and the ATR-ATRIP complex suggesting a link between circadian rhythm and the cell cycle.

Gene ID

8914

Gene Name (eCommerce)

timeless circadian regulator

Gene Name (Vector)

timeless circadian clock

Gene Symbol

TIMELESS

HGNC ID

HGNC:11813

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3627

ORF Size (bp)

3627 bp

Protein Name (eCommerce)

Protein timeless homolog

RefSeq ID

NM_003920

RefSeq Synonyms

NM_003920, NM_001330295, BC050557,

Research Areas

Cell Cycle,Cell Division,Chromatin Remodeling,DNA Damage/Repair,Signal Transduction,Transcription Factor/Regulator

Research Areas (Faceted)

signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation

Species

human

Target Sentence

Timeless was first identified in Drosophila as a transcriptional regulator involved in the fly circadian rhythm. In mice, humans and yeast, the homologs of drosophila timeless have been observed to play a role in the DNA damage checkpoint response. Human timeless has been shown to interact with the circadian clock protein cryptochrome 2 as well as the DNA checkpoint proteins Chk1 and the ATR-ATRIP complex suggesting a link between circadian rhythm and the cell cycle.

UniGene ID

Hs.118631

UniProt ID (eCommerce)

Q9UNS1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.