human TH Adenovirus

Name
Ad-h-TH

Cat No
ADV-225415

Availability
4-5 weeks

This is an Adenovirus expressing Human TH.

ADV-225415

Ad-h-TH

Ready-to-use Adenovirus expressing Human TH (tyrosine hydroxylase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

dystonia 14; DYT14; DYT5b; TH; TYH; tyrosine 3-hydroxylase; tyrosine 3-monooxygenase

Description (eCommerce)

Tyrosine Hydroxylase is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. [taken from NCBI Entrez Gene (Gene ID: 7054)].

Description (Vector)

TH is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene ID

7054

Gene Name (eCommerce)

tyrosine hydroxylase

Gene Name (Vector)

tyrosine hydroxylase

Gene Symbol

TH

HGNC ID

HGNC:11782

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1506

ORF Size (bp)

1506 bp

Protein Name (eCommerce)

Tyrosine 3-monooxygenase

RefSeq ID

NM_000360

RefSeq Synonyms

NM_199293, NM_199292, NM_000360, BC143614, BC143611, BC104967,

Research Areas

Aging,Cardiac Development,Cardiology,Cardiovascular,Hypoxia,MAPK Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,Parkinson's Disease,Prolactin Signaling,Signal Transduction

Research Areas (Faceted)

signal_transduction,cell_biology,cardiovascular,metabolism,signal_transduction,cell_biology,neurobiology,developmental_biology,signal_transduction

Species

human

Target Sentence

Tyrosine Hydroxylase is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. [taken from NCBI Entrez Gene (Gene ID: 7054)].

UniGene ID

Hs.435609

UniProt ID (eCommerce)

P07101

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.