human TBC1D23 Adenovirus
This is an Adenovirus expressing Human TBC1D23.
ADV-225087
Ad-h-TBC1D23
Ready-to-use Adenovirus expressing Human TBC1D23 (TBC1 domain family member 23). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HCV non-structural protein 4A-transactivated protein 1; HCV nonstructural protein 4A-transactivated protein 1; NS4ATP1; PCH11; TBC1 domain family member 23
Description (eCommerce)
TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NUY8].
Gene ID
55773
Gene Name (eCommerce)
TBC1 domain family member 23
Gene Name (Vector)
TBC1 domain family member 23
Gene Symbol
TBC1D23
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1644
ORF Size (bp)
1644 bp
Protein Name (eCommerce)
TBC1 domain family member 23
RefSeq ID
NM_018309
RefSeq Synonyms
NM_018309, NM_001199198, BC020955, BC010221,
Research Areas
Cell Biology
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
TBC1D23 is a putative Rab GTPase-activating protein which plays a role in vesicular trafficking and is involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1. TBC1D23 also plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes that are essential for axonal and dendritic growth. May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NUY8].
UniGene ID
Hs.477003
UniProt ID (eCommerce)
Q9NUY8
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.