human TARBP1 Adenovirus

Name 
Ad-h-TARBP1
Cat No 
ADV-224971
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human TARBP1.

ADV-224971
Ad-h-TARBP1

Ready-to-use Adenovirus expressing Human TARBP1 (TAR (HIV-1) RNA binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
probable methyltransferase TARBP1; TAR (HIV) RNA-binding protein 1; TAR RNA loop binding protein; TAR RNA-binding protein 1; TAR RNA-binding protein of 185 kDa; TRM3; TRMT3; tRNA methyltransferase 3 homolog; TRP185; TRP-185
Description (eCommerce)
TAR RNA-binding protein 1 (TARBP1) is a probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. TARBP1 may act by methylating HIV-1 TAR RNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13395].
Description (Vector)
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined.
Gene ID
6894
Gene Name (eCommerce)
TAR (HIV-1) RNA binding protein 1
Gene Name (Vector)
TAR (HIV-1) RNA binding protein 1
Gene Symbol
TARBP1
HGNC ID
HGNC:11568
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4863
ORF Size (bp)
4863 bp
Protein Name (eCommerce)
Probable methyltransferase TARBP1
RefSeq ID
NM_005646
RefSeq Synonyms
NM_005646, BC156249,
Research Areas
Methyltransferase,Neurobiology,RNA Binding,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,neurobiology,genetics,transcription_translation
Species
human
Target Sentence
TAR RNA-binding protein 1 (TARBP1) is a probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop region of TAR RNA, a region also bound by RNA polymerase II. Binding of TARBP1 and RNA polymerase II to HIV-1 TAR RNA is mutually exclusive, suggesting that TARBP1 may function alone or in conjunction with HIV-1 Tat to disengage RNA polymerase II from HIV-1 TAR RNA. TARBP1 may act by methylating HIV-1 TAR RNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13395].
UniGene ID
Hs.498115
UniProt ID (eCommerce)
Q13395

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.