human SPG20 Adenovirus
This is an Adenovirus expressing Human SPG20.
ADV-224161
Ad-h-SPG20
Ready-to-use Adenovirus expressing Human SPG20 (spastic paraplegia 20 (Troyer syndrome)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
spartin; spastic paraplegia 20 (Troyer syndrome); Spastic paraplegia 20 protein; SPG20; TAHCCP1; trans-activated by hepatitis C virus core protein 1
Description (eCommerce)
Spastic paraplegia 20 protein (SPG20) is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Mutations associated with the SPG20 gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome) [taken from NCBI Entrez Gene (Gene ID: 23111)].
Description (Vector)
SPG20 encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).
Gene ID
23111
Gene Name (eCommerce)
spartin
Gene Name (Vector)
spastic paraplegia 20 (Troyer syndrome)
Gene Symbol
SPG20
HGNC ID
HGNC:18514
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2001
ORF Size (bp)
2001 bp
Protein Name (eCommerce)
Spartin
RefSeq ID
NM_015087
RefSeq Synonyms
NM_015087, NM_001142296, NM_001142295, NM_001142294, BC047083,
Research Areas
Apoptosis,Cell Biology,EGFR Signaling,Mitochondrion,Neurobiology,Neurodegeneration,Signal Transduction,Ubiquitination
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Spastic paraplegia 20 protein (SPG20) is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Mutations associated with the SPG20 gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome) [taken from NCBI Entrez Gene (Gene ID: 23111)].
UniGene ID
Hs.440414
UniProt ID (eCommerce)
Q8N0X7
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.