human SNW1 Adenovirus

Name 
Ad-h-SNW1
Cat No 
ADV-223910
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human SNW1.

ADV-223910
Ad-h-SNW1

Ready-to-use Adenovirus expressing Human SNW1 (SNW domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Bx42; FUN20; homolog of Drosophila BX42; NCOA-62; nuclear protein SkiP; nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; Prp45; PRPF45; SKI interacting protein; ski-interacting protein; SKIIP; SKIP; SKIP1; SNW domain-containing protein 1
Description (eCommerce)
NCOA62 is an integral component of the splicesome that functions in pre-mRNA splicing. NCOA62 has also been demonstrated to function as a coactivator of the Notch transcription factor and the vitamin D nuclear receptor. Additionally, NCOA2 exhibits transcriptional repression activity and associates with the N-Cor and SMRT corepressors. Recent evidence suggests a role for NCOA62 in transcription elongation.
Description (Vector)
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
Gene ID
22938
Gene Name (eCommerce)
SNW domain containing 1
Gene Name (Vector)
SNW domain containing 1
Gene Symbol
SNW1
HGNC ID
HGNC:16696
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1611
ORF Size (bp)
1611 bp
Protein Name (eCommerce)
SNW domain-containing protein 1
RefSeq ID
NM_012245
RefSeq Synonyms
NM_012245, NM_001318844, BC108903,
Research Areas
Cancer,Gene Expression,Host-Virus Interactions,mRNA Processing,mRNA Splicing,Neurobiology,Neurodevelopment,Neurogenesis,Notch Signaling,Nuclear Receptor Coactivators,RNA Processing,Signal Transduction,Spliceosome,TGF-beta Signaling,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
NCOA62 is an integral component of the splicesome that functions in pre-mRNA splicing. NCOA62 has also been demonstrated to function as a coactivator of the Notch transcription factor and the vitamin D nuclear receptor. Additionally, NCOA2 exhibits transcriptional repression activity and associates with the N-Cor and SMRT corepressors. Recent evidence suggests a role for NCOA62 in transcription elongation.
UniGene ID
Hs.445498
UniProt ID (eCommerce)
Q13573

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.