human EIF4G2 Adenovirus
This is an Adenovirus expressing Human EIF4G2.
ADV-223852
Ad-h-EIF4G2
Ready-to-use Adenovirus expressing Human EIF4G2 (eukaryotic translation initiation factor 4 gamma 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AAG1; aging-associated protein 1; DAP5; DAP-5; death-associated protein 5; eIF4G 2; eIF-4G 2; eIF-4-gamma 2; eukaryotic translation initiation factor 4 gamma 2; eukaryotic translation initiation factor 4G-like 1; NAT1; P97
Description (eCommerce)
DAP5 (death associated protein 5) is also known as eukaryotic translation initiation factor 4 gamma 2. DAP5 has been found to function as a general repressor of translation and appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis, and viral infection.
Description (Vector)
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Gene ID
1982
Gene Name (eCommerce)
eukaryotic translation initiation factor 4 gamma 2
Gene Name (Vector)
eukaryotic translation initiation factor 4 gamma 2
Gene Symbol
EIF4G2
HGNC ID
HGNC:3297
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2106
ORF Size (bp)
2106 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 4 gamma 2
RefSeq ID
NM_001418
RefSeq Synonyms
NM_001418, NM_001172705, NM_001042559, BC111548, BC111415, BC065276, BC043149, BC039851, BC018975, BC018746,
Research Areas
Apoptosis,Cardiology,Cardiovascular,Cell Cycle,Cytokine Signaling,Host-Virus Interactions,IFN Signaling,Immunology,RNA Processing,RNA Transport,Signal Transduction,Translational Control
Research Areas (Faceted)
cardiovascular,cell_biology,cell_cycle,genetics,transcription_translation,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
DAP5 (death associated protein 5) is also known as eukaryotic translation initiation factor 4 gamma 2. DAP5 has been found to function as a general repressor of translation and appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis, and viral infection.
UniGene ID
Hs.183684
UniProt ID (eCommerce)
P78344
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.