human SESN1 Adenovirus

Name
Ad-h-SESN1

Cat No
ADV-222724

Availability
4-5 weeks

This is an Adenovirus expressing Human SESN1.

ADV-222724

Ad-h-SESN1

Ready-to-use Adenovirus expressing Human SESN1 (sestrin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

PA26; SEST1

Description (Vector)

SESN1 encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

27244

Gene Name (Vector)

sestrin 1

Gene Symbol

SESN1

HGNC ID

HGNC:21595

ORF Size (aa)

1656

ORF Size (bp)

1656 bp

RefSeq ID

NM_014454

RefSeq Synonyms

NM_014454, NM_001199934, NM_001199933, BC113569, BC112036,

Species

human

UniGene ID

Hs.591336

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.