human SENP6 Adenovirus
This is an Adenovirus expressing Human SENP6.
ADV-222577
Ad-h-SENP6
Ready-to-use Adenovirus expressing Human SENP6 (SUMO1/sentrin specific peptidase 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SSP1; SUSP1
Description (Vector)
Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 (PubMed 10799485)). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 (PubMed 18799455)).(supplied by OMIM, Jun 2009)
Gene ID
26054
Gene Name (Vector)
SUMO1/sentrin specific peptidase 6
Gene Symbol
SENP6
HGNC ID
HGNC:20944
ORF Size (aa)
3318
ORF Size (bp)
3318 bp
RefSeq ID
NM_015571
RefSeq Synonyms
NM_015571, NM_001304792, NM_001100409, BC028583,
Species
human
UniGene ID
Hs.485784
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.