human SEMA4D Adenovirus

Name 
Ad-h-SEMA4D
Cat No 
ADV-222554
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human SEMA4D.

ADV-222554
Ad-h-SEMA4D

Ready-to-use Adenovirus expressing Human SEMA4D (semaphorin 4D). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
A8; BB18; C9orf164; CD antigen CD100; CD100; COLL4; coll-4; GR3; M-sema-G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; SEMAJ; semaphorin-4D
Description (eCommerce)
Sema4D (Semaphorin-4D) is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Sema4D promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Sema4D regulates dendrite and axon branching and morphogenesis. It promotes the migration of cerebellar granule cells and of endothelial cells. In the immune system Sema4D induces B-cells to aggregate and improves their viability (in vitro). Sema4D also promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92854].
Gene ID
10507
Gene Name (eCommerce)
semaphorin 4D
Gene Name (Vector)
semaphorin 4D
Gene Symbol
SEMA4D
HGNC ID
HGNC:10732
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2589
ORF Size (bp)
2589 bp
Protein Name (eCommerce)
Semaphorin-4D
RefSeq ID
NM_006378
RefSeq Synonyms
NM_006378, NM_001142287, BC054500,
Research Areas
Apoptosis,Axon Guidance,Immunology,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology,immunology,developmental_biology
Species
human
Target Sentence
Sema4D (Semaphorin-4D) is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Sema4D promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Sema4D regulates dendrite and axon branching and morphogenesis. It promotes the migration of cerebellar granule cells and of endothelial cells. In the immune system Sema4D induces B-cells to aggregate and improves their viability (in vitro). Sema4D also promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92854].
UniGene ID
Hs.494406
UniProt ID (eCommerce)
Q92854

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.