human SDHB Adenovirus

Name
Ad-h-SDHB

Cat No
ADV-222438

Availability
4-5 weeks

This is an Adenovirus expressing Human SDHB.

ADV-222438

Ad-h-SDHB

Ready-to-use Adenovirus expressing Human SDHB (succinate dehydrogenase complex iron sulfur subunit B). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP

Description (Vector)

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Gene ID

6390

Gene Name (Vector)

succinate dehydrogenase complex iron sulfur subunit B

Gene Symbol

SDHB

HGNC ID

HGNC:10681

ORF Size (aa)

843

ORF Size (bp)

843 bp

RefSeq ID

NM_003000

RefSeq Synonyms

NM_003000, BC007840,

Species

human

UniGene ID

Hs.465924

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.