human SLC46A1 Adenovirus

Name 
Ad-h-SLC46A1
Cat No 
ADV-222255
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human SLC46A1.

ADV-222255
Ad-h-SLC46A1

Ready-to-use Adenovirus expressing Human SLC46A1 (solute carrier family 46 member 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
G21; HCP1; heme carrier protein 1; PCFT; PCFT/HCP1; proton-coupled folate transporter; solute carrier family 46 (folate transporter), member 1; Solute carrier family 46 member 1
Description (eCommerce)
Solute carrier family 46 member 1 (SLC46A1) has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. SLC46A1 shows a higher affinity for folate than heme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96NT5].
Description (Vector)
SLC46A1 encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption (HFM) disease. HFM is characterized by folate deficiency due to reduced intestinal folate absorption and subsequent anemia, hypoimmunoglobulinemia, and recurrent infections. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
113235
Gene Name (eCommerce)
solute carrier family 46 member 1
Gene Name (Vector)
solute carrier family 46 member 1
Gene Symbol
SLC46A1
HGNC ID
HGNC:30521
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1296
ORF Size (bp)
1296 bp
Protein Name (eCommerce)
Proton-coupled folate transporter
RefSeq ID
NM_080669
RefSeq Synonyms
NM_080669, NM_001242366, BC010691,
Research Areas
Metabolism/Metabolic Process,Transport
Research Areas (Faceted)
metabolism,cell_biology
Species
human
Target Sentence
Solute carrier family 46 member 1 (SLC46A1) has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. SLC46A1 shows a higher affinity for folate than heme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96NT5].
UniGene ID
Hs.446689
UniProt ID (eCommerce)
Q96NT5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.