human RUNX3 Adenovirus
This is an Adenovirus expressing Human RUNX3.
ADV-222118
Ad-h-RUNX3
Ready-to-use Adenovirus expressing Human RUNX3 (runt related transcription factor 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
acute myeloid leukemia 2 protein; acute myeloid leukemia gene 2; AML2; CBFA3; CBF-alpha-3; core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 3; oncogene AML-2; PEA2 alpha C; PEA2-alpha C; PEBP2 alpha C; PEBP2aC; PEBP2-alpha C; polyomavirus enhancer-binding protein 2 alpha C subunit; runt-related transcription factor 3; SL3/AKV core-binding factor alpha C subunit; SL3-3 enhancer factor 1 alpha C subunit; transcription factor AML2
Description (eCommerce)
RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of RUNX3 and CBFB forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. This complex binding can either activate or suppress transcription to control cellular proliferation and/or differentiation, in particular cytotoxic T cell differentiation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13761].
Description (Vector)
RUNX3 encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
864
Gene Name (eCommerce)
runt related transcription factor 3
Gene Name (Vector)
runt related transcription factor 3
Gene Symbol
RUNX3
HGNC ID
HGNC:10473
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1290
ORF Size (bp)
1290 bp
Protein Name (eCommerce)
Runt-related transcription factor 3
RefSeq ID
NM_004350
RefSeq Synonyms
NM_004350, NM_001320672, NM_001031680, BC013362,
Research Areas
Apoptosis,Axon Guidance,Cell Cycle,Neurobiology,Neurodevelopment,RNA Binding,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology,cell_cycle,neurobiology,developmental_biology,genetics,signal_transduction,immunology,genetics,transcription_translation
Species
human
Target Sentence
RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of RUNX3 and CBFB forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. This complex binding can either activate or suppress transcription to control cellular proliferation and/or differentiation, in particular cytotoxic T cell differentiation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13761].
UniGene ID
Hs.170019
UniProt ID (eCommerce)
Q13761
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.