human RTF1 Adenovirus

Name
Ad-h-RTF1

Cat No
ADV-222081

Availability
4-5 weeks

This is an Adenovirus expressing Human RTF1.

ADV-222081

Ad-h-RTF1

Ready-to-use Adenovirus expressing Human RTF1 (RTF1 homolog, Paf1/RNA polymerase II complex component). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

GTL7; KIAA0252; ortholog of mouse gene trap locus 7; RNA polymerase-associated protein RTF1 homolog; Rtf1, Paf1/RNA polymerase II complex component, homolog

Description (eCommerce)

In yeast, Rtf1 is a component of the Paf1/RNA polymerase II complex. The Paf1 complex interacts with RNA polymerase II and functions to modify chromatin during transcription. Rtf1 appears to be important for histone H2B ubiquitination by Rad6 and for methylation of histone H3 catalyzed by the Set1/COMPASS complex that functions during transcription elongation.

Description (Vector)

This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA.

Gene ID

23168

Gene Name (eCommerce)

RTF1 homolog, Paf1/RNA polymerase II complex component

Gene Name (Vector)

RTF1 homolog, Paf1/RNA polymerase II complex component

Gene Symbol

RTF1

HGNC ID

HGNC:28996

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1758

ORF Size (bp)

1758 bp

Protein Name (eCommerce)

RNA polymerase-associated protein RTF1 homolog

RefSeq ID

NM_015138

RefSeq Synonyms

NM_015138, BC015052,

Research Areas

Histone Modification,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling

Research Areas (Faceted)

cell_biology,signal_transduction,transcription_translation

Species

human

Target Sentence

In yeast, Rtf1 is a component of the Paf1/RNA polymerase II complex. The Paf1 complex interacts with RNA polymerase II and functions to modify chromatin during transcription. Rtf1 appears to be important for histone H2B ubiquitination by Rad6 and for methylation of histone H3 catalyzed by the Set1/COMPASS complex that functions during transcription elongation.

UniGene ID

Hs.511096

UniProt ID (eCommerce)

Q92541

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.