human RIPK3 Adenovirus
This is an Adenovirus expressing Human RIPK3.
ADV-221256
Ad-h-RIPK3
Ready-to-use Adenovirus expressing Human RIPK3 (receptor interacting serine/threonine kinase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; RIP3; RIP-3; RIP-like protein kinase 3
Description (eCommerce)
Receptor-interacting serine/threonine-protein kinase 3 (RIP3) is essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIP3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIP3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y572].
Description (Vector)
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.
Gene ID
11035
Gene Name (eCommerce)
receptor interacting serine/threonine kinase 3
Gene Name (Vector)
receptor interacting serine/threonine kinase 3
Gene Symbol
RIPK3
HGNC ID
HGNC:10021
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1557
ORF Size (bp)
1557 bp
Protein Name (eCommerce)
Receptor-interacting serine/threonine-protein kinase 3
RefSeq ID
NM_006871
RefSeq Synonyms
NM_006871, BC062584, BC041668,
Research Areas
Apoptosis,EPO Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Mitochondrion,NF-kB Signaling,Signal Transduction,TNF Signaling,Toll-like Receptor Signaling,VEGF Signaling
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Receptor-interacting serine/threonine-protein kinase 3 (RIP3) is essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIP3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIP3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y572].
UniGene ID
Hs.268551
UniProt ID (eCommerce)
Q9Y572
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.