human RASAL1 Adenovirus
This is an Adenovirus expressing Human RASAL1.
ADV-220766
Ad-h-RASAL1
Ready-to-use Adenovirus expressing Human RASAL1 (RAS protein activator like 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GAP1 like protein; ras GTPase-activating-like protein; RAS protein activator like 1; RASAL; rasGAP-activating-like protein 1
Description (eCommerce)
RASAL1 is a member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, RASAL1 enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, RASAL1 is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010] [taken from NCBI Entrez Gene (Gene ID: 8437)].
Description (Vector)
RASAL1 is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described
Gene ID
8437
Gene Name (eCommerce)
RAS protein activator like 1
Gene Name (Vector)
RAS protein activator like 1
Gene Symbol
RASAL1
HGNC ID
HGNC:9873
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2415
ORF Size (bp)
2415 bp
Protein Name (eCommerce)
RasGAP-activating-like protein 1
RefSeq ID
NM_004658
RefSeq Synonyms
NM_004658, NM_001301202, NM_001193521, NM_001193520, BC143261, BC093724, BC014420,
Research Areas
Signal Transduction,Zinc-finger
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
RASAL1 is a member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, RASAL1 enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, RASAL1 is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010] [taken from NCBI Entrez Gene (Gene ID: 8437)].
UniGene ID
Hs.528693
UniProt ID (eCommerce)
O95294
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.