human RAPGEF2 Adenovirus

Name 
Ad-h-RAPGEF2
Cat No 
ADV-220731
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human RAPGEF2.

ADV-220731
Ad-h-RAPGEF2

Ready-to-use Adenovirus expressing Human RAPGEF2 (Rap guanine nucleotide exchange factor 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CNrasGEF; cyclic nucleotide ras GEF; neural RAP guanine nucleotide exchange protein; nRap GEP; NRAPGEP; PDZ domain containing guanine nucleotide exchange factor (GEF) 1; PDZ domain-containing guanine nucleotide exchange factor 1; PDZGEF1; PDZ-GEF1; RA(Ras/Rap1A-associating)-GEF; RAGEF; RA-GEF; RA-GEF-1; Rap guanine nucleotide exchange factor (GEF) 2; rap guanine nucleotide exchange factor 2; Rap-GEP; ras/Rap1-associating GEF-1
Description (eCommerce)
PDZ-GEF1 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity.
Description (Vector)
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 (PubMed 10934204)).(supplied by OMIM, Mar 2008)
Gene ID
9693
Gene Name (eCommerce)
Rap guanine nucleotide exchange factor 2
Gene Name (Vector)
Rap guanine nucleotide exchange factor 2
Gene Symbol
RAPGEF2
HGNC ID
HGNC:16854
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4461
ORF Size (bp)
4461 bp
Protein Name (eCommerce)
Rap guanine nucleotide exchange factor 2
RefSeq ID
NM_014247
RefSeq Synonyms
NM_014247, BC117321,
Research Areas
MAPK Signaling,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology,developmental_biology
Species
human
Target Sentence
PDZ-GEF1 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity.
UniGene ID
Hs.113912
UniProt ID (eCommerce)
Q9Y4G8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.