human PYCARD Adenovirus

Name
Ad-h-PYCARD

Cat No
ADV-220439

Availability
4-5 weeks

This is an Adenovirus expressing Human PYCARD.

ADV-220439

Ad-h-PYCARD

Ready-to-use Adenovirus expressing Human PYCARD (PYD and CARD domain containing). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ASC; CARD5; TMS; TMS-1; TMS1

Description (Vector)

PYCARD encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

29108

Gene Name (Vector)

PYD and CARD domain containing

Gene Symbol

PYCARD

HGNC ID

HGNC:16608

ORF Size (aa)

408

RefSeq ID

NM_013258

RefSeq Synonyms

NM_145182, NM_013258, BC004470,

Species

human

UniGene ID

Hs.499094

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.