human PTK2B Adenovirus

CADTK; CAKB; CAK-beta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; FADK 2; FADK2; FAK2; focal adhesion kinase 2; PKB; proline-rich tyrosine kinase 2; protein kinase B; protein-tyrosine kinase 2-beta; PTK; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; related adhesion focal tyrosine kinase

Protein tyrosine kinase 2 (PYK2) is a non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. PYK2 plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It is required for normal macrophage polarization and migration towards sites of inflammation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14289].

PTK2B encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

2185

protein tyrosine kinase 2 beta

protein tyrosine kinase 2 beta

PTK2B

HGNC:9612

9606.0

3030

3030 bp

Protein-tyrosine kinase 2-beta

NM_004103

NM_173176, NM_173175, NM_173174, NM_004103, BC042599, BC036651,

Angiogenesis,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Cancer,Cardiovascular,Cytokine Signaling,Cytoskeleton,EGFR Signaling,EPO Signaling,FGF Signaling,GnRH Signaling,HGF Signaling,Host-Virus Interactions,Hypoxia,Immunology,Interleukin Signaling,JAK-STAT Signaling,JNK Signaling,Kinase/Phosphatase,MAPK Signaling,Neurobiology,Neurodevelopment,Prostate Cancer,Signal Transduction,T-cell Receptor Signaling,Translational Control,VEGF Signaling

cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation

human

Protein tyrosine kinase 2 (PYK2) is a non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. PYK2 plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It is required for normal macrophage polarization and migration towards sites of inflammation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14289].

Hs.491322

Q14289