human PTK2 Adenovirus

FADK; FADK 1; FAK; FAK1; FAK-related non-kinase polypeptide; focal adhesion kinase 1; focal adhesion kinase isoform FAK-Del33; focal adhesion kinase-related nonkinase; FRNK; p125FAK; pp125FAK; PPP1R71; protein phosphatase 1 regulatory subunit 71; Protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2

Focal adhesion kinase (FAK) is a non-receptor protein-tyrosine kinase that localizes to the cytoplasm and is concentrated in focal adhesions, macromolecular assemblies that form a communicative link between the cell and the extracellular matrix. FAK signaling is stimulated by integrin-mediated responses, as well as growth factors, chemokines, and G-protein-linked receptors. FAK signaling influences cell motility, invasion, and survival.

PTK2 encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.

5747

protein tyrosine kinase 2

protein tyrosine kinase 2

PTK2

HGNC:9611

9606.0

2043

2043 bp

Focal adhesion kinase 1

NM_005607

NM_153831, NM_005607, NM_001316342, NM_001199649, BC035404, BC028733,

Angiogenesis,Apoptosis,Axon Guidance,Axonogenesis,B-cell Receptor Signaling,Breast Cancer,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Cytoskeleton,EGFR Signaling,EPO Signaling,Fc Receptor Signaling,HGF Signaling,Host-Virus Interactions,Hypoxia,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,Lung Cancer,MAPK Signaling,Neurobiology,Neurodevelopment,PI3K/Akt Signaling,Prolactin Signaling,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Transcriptional Misregulation in Cancer,VEGF Signaling

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation

human

Focal adhesion kinase (FAK) is a non-receptor protein-tyrosine kinase that localizes to the cytoplasm and is concentrated in focal adhesions, macromolecular assemblies that form a communicative link between the cell and the extracellular matrix. FAK signaling is stimulated by integrin-mediated responses, as well as growth factors, chemokines, and G-protein-linked receptors. FAK signaling influences cell motility, invasion, and survival.

Hs.395482

Q05397