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human PSPC1 Adenovirus

Name 
Ad-h-PSPC1
Cat No 
ADV-220195
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PSPC1.

ADV-220195
Ad-h-PSPC1

Ready-to-use Adenovirus expressing Human PSPC1 (paraspeckle component 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
paraspeckle component 1; paraspeckle protein 1; PSP1
Description (eCommerce)
Paraspeckle protein 1 (PSP1), also known as paraspeckle component 1 (PSPC1) is localized to punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in a RNA-dependent manner [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8WXF1].
Description (Vector)
PSPC1 encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified.
Gene ID
55269
Gene Name (eCommerce)
paraspeckle component 1
Gene Name (Vector)
paraspeckle component 1
Gene Symbol
PSPC1
HGNC ID
HGNC:20320
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1182
ORF Size (bp)
1182 bp
Protein Name (eCommerce)
Paraspeckle component 1
RefSeq ID
NM_001042414
RefSeq Synonyms
NM_001042414, BC014184,
Research Areas
RNA Binding,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Paraspeckle protein 1 (PSP1), also known as paraspeckle component 1 (PSPC1) is localized to punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in a RNA-dependent manner [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q8WXF1].
UniGene ID
Hs.213198
UniProt ID (eCommerce)
Q8WXF1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.