human PRPF8 Adenovirus

Name 
Ad-h-PRPF8
Cat No 
ADV-219964
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PRPF8.

ADV-219964
Ad-h-PRPF8

Ready-to-use Adenovirus expressing Human PRPF8 (pre-mRNA processing factor 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
220 kDa U5 snRNP-specific protein; apoptosis-regulated protein 1; apoptosis-regulated protein 2; HPRP8; p220; precursor mRNA processing protein; pre-mRNA-processing-splicing factor 8; PRP8; PRP8 homolog; PRP8 pre-mRNA processing factor 8 homolog; PRPC8; RP13; SNRNP220; splicing factor Prp8; U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p
Description (eCommerce)
Pre-mRNA-processing-splicing factor 8 (PRPF8) is a central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. PRPF8 interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TCS8].
Description (Vector)
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.
Gene ID
10594
Gene Name (eCommerce)
pre-mRNA processing factor 8
Gene Name (Vector)
pre-mRNA processing factor 8
Gene Symbol
PRPF8
HGNC ID
HGNC:17340
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7008
ORF Size (bp)
7008 bp
Protein Name (eCommerce)
Pre-mRNA-processing-splicing factor 8
RefSeq ID
NM_006445
RefSeq Synonyms
NM_006445, BC064370,
Research Areas
Gene Expression,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Pre-mRNA-processing-splicing factor 8 (PRPF8) is a central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. PRPF8 interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8TCS8].
UniGene ID
Hs.181368
UniProt ID (eCommerce)
Q6P2Q9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.