human PRKAR1A Adenovirus

ACRDYS1; ADOHR; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; cAMP-dependent protein kinase type I-alpha regulatory subunit; CAR; Carney complex type 1; CNC; CNC1; epididymis secretory sperm binding protein; PKR1; PPNAD1; PRKAR1; protein kinase A type 1a regulatory subunit; protein kinase, cAMP-dependent, regulatory subunit type I alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha; tissue-specific extinguisher 1; TSE1

cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) is the regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. PRKAR1A is also known as tissue-specific extinguisher 1 (TSE1); PRKAR1A was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in PRKAR1A cause Carney complex (CNC), a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P10644].

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.

5573

protein kinase cAMP-dependent type I regulatory subunit alpha

protein kinase cAMP-dependent type I regulatory subunit alpha

PRKAR1A

HGNC:9388

9606.0

1146

1146 bp

cAMP-dependent protein kinase type I-alpha regulatory subunit

NM_002734

NM_212472, NM_212471, NM_002734, NM_001278433, NM_001276290, NM_001276289, BC093042, BC036285,

Apoptosis,Breast Cancer,Cancer,Cardiology,Cardiovascular,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,FGF Signaling,GPCR Signaling,Hedgehog Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Metabolism/Metabolic Process,Neurobiology,NGF Signaling,PDGF Signaling,Signal Transduction,Transcription Factor/Regulator,VEGF Signaling

cancer,cardiovascular,cell_biology,immunology,metabolism,neurobiology,signal_transduction,transcription_translation

human

cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) is the regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. PRKAR1A is also known as tissue-specific extinguisher 1 (TSE1); PRKAR1A was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in PRKAR1A cause Carney complex (CNC), a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P10644].

Hs.659124

P10644