human PPM2C Adenovirus
This is an Adenovirus expressing Human GPR78.
ADV-219591
Ad-h-PPM2C
Ready-to-use Adenovirus expressing Human PDP1 (pyruvate dehyrogenase phosphatase catalytic subunit 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PDH; PDP; PDPC; PPM2A; PPM2C
Description (Vector)
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
54704
Gene Name (Vector)
pyruvate dehyrogenase phosphatase catalytic subunit 1
Gene Symbol
PDP1
HGNC ID
HGNC:9279
ORF Size (aa)
1614
ORF Size (bp)
1614 bp
RefSeq ID
NM_018444
RefSeq Synonyms
NM_018444, NM_001161781, NM_001161780, NM_001161779, NM_001161778, BC098343, BC047619,
Species
human
UniGene ID
Hs.22265
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.