human PPL Adenovirus
This is an Adenovirus expressing Human PPL.
ADV-219570
Ad-h-PPL
Ready-to-use Adenovirus expressing Human PPL (periplakin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor protein; periplakin
Description (eCommerce)
Periplakin is a protein that localizes to the desmosomes and interdesomosomal plasma membrane of keratinocytes in the cornified layer of the epidermis. Periplakin belongs to the plakin family of cytolinker proteins that function as a link between cytoskeletal networks and membrane-associated adhesive sites. Periplakin has been reported to interact with AKT1/PKB and may function in facilitating AKT1/PKB signaling.
Description (Vector)
PPL is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
Gene ID
5493
Gene Name (eCommerce)
periplakin
Gene Name (Vector)
periplakin
Gene Symbol
PPL
HGNC ID
HGNC:9273
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5271
ORF Size (bp)
5271 bp
Protein Name (eCommerce)
Periplakin
RefSeq ID
NM_002705
RefSeq Synonyms
NM_002705, BC114620,
Research Areas
Cytoskeleton,Mitochondrion
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Periplakin is a protein that localizes to the desmosomes and interdesomosomal plasma membrane of keratinocytes in the cornified layer of the epidermis. Periplakin belongs to the plakin family of cytolinker proteins that function as a link between cytoskeletal networks and membrane-associated adhesive sites. Periplakin has been reported to interact with AKT1/PKB and may function in facilitating AKT1/PKB signaling.
UniGene ID
Hs.192233
UniProt ID (eCommerce)
O60437
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.