Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

PLP1

Gene Name

proteolipid protein 1

Gene ID

5354

Gene Synonyms

GPM6C; HLD1; MMPL; PLP; PLP/DM20; PMD; SPG2

ORF Size

729 bp

RefSeq#

BC002665

Gene Description

PLP1 encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.

UniGene ID

Hs.1787

HGNC ID

HGNC:9086