human PKD2 Adenovirus

Name 
Ad-h-PKD2
Cat No 
ADV-219021
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PKD2.

ADV-219021
Ad-h-PKD2

Ready-to-use Adenovirus expressing Human PKD2 (polycystin 2, transient receptor potential cation channel). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
APKD2; autosomal dominant polycystic kidney disease type II protein; PC2; Pc-2; PKD4; polycystic kidney disease 2 (autosomal dominant); Polycystic kidney disease 2 protein; polycystin-2; Polycystwin; R48321; transient receptor potential cation channel subfamily P member 2; TRPP2
Description (eCommerce)
Polycystin-2 is a calcium permeable cation channel. Defects in the Polycystin-2 gene, PKD2, are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) which is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occur in the liver and other organs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13563].
Description (Vector)
PKD2 encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.
Gene ID
5311
Gene Name (eCommerce)
polycystin 2, transient receptor potential cation channel
Gene Name (Vector)
polycystin 2, transient receptor potential cation channel
Gene Symbol
PKD2
HGNC ID
HGNC:9009
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2907
ORF Size (bp)
2907 bp
Protein Name (eCommerce)
Polycystin-2
RefSeq ID
NM_000297
RefSeq Synonyms
NM_000297, BC112263, BC112261, BC111454,
Research Areas
Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Cytoskeleton,JAK-STAT Signaling,Neurobiology,Neurodevelopment,Signal Transduction,Transport
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,neurobiology,signal_transduction
Species
human
Target Sentence
Polycystin-2 is a calcium permeable cation channel. Defects in the Polycystin-2 gene, PKD2, are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) which is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occur in the liver and other organs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13563].
UniGene ID
Hs.181272
UniProt ID (eCommerce)
Q13563

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.