human PITRM1 Adenovirus

Name 
Ad-h-PITRM1
Cat No 
ADV-219000
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human GNA12.

ADV-219000
Ad-h-PITRM1

Ready-to-use Adenovirus expressing Human PITRM1 (pitrilysin metallopeptidase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
hMP1; hPreP; Metalloprotease 1; metalloprotease 1 (pitrilysin family); MP1; pitrilysin metalloproteinase 1; PreP; PreP peptidasome; presequence protease, mitochondrial
Description (eCommerce)
Pitrilysin metalloproteinase 1 (PITRM1) is an ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. PITRM1 also degrades other unstructured peptides. It is specific for peptides in the range of 10 to 65 residues. It is able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. PTMRM shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5JRX3].
Gene ID
10531
Gene Name (eCommerce)
pitrilysin metallopeptidase 1
Gene Name (Vector)
pitrilysin metallopeptidase 1
Gene Symbol
PITRM1
HGNC ID
HGNC:17663
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1605
ORF Size (bp)
1605 bp
Protein Name (eCommerce)
Presequence protease, mitochondrial
RefSeq ID
NM_014889
RefSeq Synonyms
NM_014889, NM_001242309, NM_001242307, BC113369, BC111987, BC095422, BC005025, BC001150,
Research Areas
Mitochondrion
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Pitrilysin metalloproteinase 1 (PITRM1) is an ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. PITRM1 also degrades other unstructured peptides. It is specific for peptides in the range of 10 to 65 residues. It is able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. PTMRM shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q5JRX3].
UniGene ID
Hs.528300
UniProt ID (eCommerce)
Q5JRX3

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.