human PDE8A Adenovirus

Name 
Ad-h-PDE8A
Cat No 
ADV-218495
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PDE8A.

ADV-218495
Ad-h-PDE8A

Ready-to-use Adenovirus expressing Human PDE8A (phosphodiesterase 8A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cAMP-specific cyclic nucleotide phosphodiesterase 8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; HsT19550
Description (eCommerce)
Phosphodiesterase 8A (PDE8A) is a member of a large family of phosphodiesterases (PDEs) that regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction [taken from NCBI Entrez Gene (Gene ID: 5151)].
Description (Vector)
PDE8A belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
5151
Gene Name (eCommerce)
phosphodiesterase 8A
Gene Name (Vector)
phosphodiesterase 8A
Gene Symbol
PDE8A
HGNC ID
HGNC:8793
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2490
ORF Size (bp)
2490 bp
Protein Name (eCommerce)
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
RefSeq ID
NM_002605
RefSeq Synonyms
NM_173454, NM_002605, NM_001243137, BC075822, BC060762,
Research Areas
GPCR Signaling,Metabolism/Metabolic Process,Neurobiology,Signal Transduction
Research Areas (Faceted)
cell_biology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Phosphodiesterase 8A (PDE8A) is a member of a large family of phosphodiesterases (PDEs) that regulate the intracellular levels of cAMP and cGMP. These cyclic nucleotides play an important role as second messengers in multiple physiologic processes, including regulation of vascular resistance, cardiac output, visceral motility, immune response, inflammation, neuroplasticity, vision, and reproduction [taken from NCBI Entrez Gene (Gene ID: 5151)].
UniGene ID
Hs.9333
UniProt ID (eCommerce)
O60658

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.